Design and in Vitro Evaluations of Sustained Release Film Coated Tablets of Verapamil Hydrochloride

B. S. Venkateswarlu*, Jaykar B., Pasupathi A., Margret Chandira R., Palanisamy P.


An attempt was to formulate the sustained release tablet of verapamil hydrochloride by using the wet granulation method for Antihypertension. In this formula tablet provide the loading dose by immediate drug release and provide maintenance dose up to 15 hours by extended release. The drug excipient compatability study was carried out with HPLC method, there was no interaction found. Immediate release fraction was formulated by using cross carmellose sodium as a disintegrating agent and extended release fraction was formulated by using Hypromellose E4 as a rate controlling polymer. The granules were evaluated for angle of repose, bulk density, tapped density and compressibility index showed satisfactory results. The prepared sustained release tablets were evaluated as thickness, hardness, friability and in vitro release studies. In vitro dissolution study was carried out for 15 hrs using USP dissolution apparatus type II with 0.1 N HCl and 7.4 pH phosphate buffer as dissolution medium.  From the dissolution profile, f2 & f3 values were calculated which were within the specification. Stability study was carried out for the optimized formulation at 40°C/75% RH for 1 month, the result shows that there was no significant change in physical and chemical parameter of the tablet.


Sustained Release Tablet; Antihypertension; Hypromellose E4; Wet Granulation.

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