Hepato Protective Activity of Various Extracts of Indigofera barberi Gamble against D-Galactosamine Induced Toxicity In Rats

Srinivasan N.*, Sathyanarayana D.

Abstract


Medicinal plants have been found to possess hepatoprotective activity to varying degrees. The aim of the present study is to investigate the hepatoprotective effects of Indigofera barberi Gamble (aerial part of the plants extracts) in D-Galactosamine induced hepatic toxicity in Wistar albino rats. The rats received a single dose of D-Galactosamine (400 mg/kg, i.p) to induce hepatotoxicity; Indigofera barberi Gamble petroleum ether, chloroform and ethanol extracts (200 mg/kg, p.o) individually and Silymarin (25 mg/kg, i.p.) were administered after the injection of D-Galactosamine. It was found that D-Galactosamine induced hepatic damage resulted in a significant increase in the activity of AST, ALT, ALP, TB and LDH (p<0.01); decrease in total protein. Indigofera barberi Gamble ethanolic extracts treatment attenuated the protective activity against D-Galactosamine induced hepatotoxicity in rats similar that of standard Silymarin. Whereas animal pretreatment with petroleum ether and chloroform extracts of Indigofera barberi did not change above mentioned parameters significantly. Thus the present study provides a scientific rationale for the traditional use of this plant in the management of liver diseases.

Keywords


D-Galactosamine; Silymarin; Indigofera barberi; Liver toxicity; ethanolic extract.

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