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Isolation and optimization of catechins from Acacia catechu and its antioxidant and anti-ageing properties in vitro

Balaji Surya Durgarao Tota, Durga Prasad V.K Y

Abstract


Catechin is a polyphenol antioxidant plant metabolite which extracted from A. catechu, a hot water extract of red heartwood of Acacia catechu Willd. It is evident from the literature survey that the catechin is a biologically important polyphenolic compound. Aging is a complex biological phenomenon, an inevitable process. Numerous studies have reported that continuous exposure to reactive oxygen species can stimulate skin aging and that excessive accumulation of fat can cause an impaired skin barrier and tissue structure alterations. Thus, the maintenance of antioxidant homeostasis and the suppression of adipose accumulation are important strategies for skin anti-aging. In our study, a fairly simple, but a unique process had developed the highly purified actives, Catechin, and to prove the synergistic applications of highly purified catechin with other novel anti-oxidants notably Ascorbic acid. In vitrostudies performed with these compounds exhibited in anti-elastase assay.

 


Keywords


Acacia catechu Willd., Catechin, Antioxidant studies, anti-elastase assay

References


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Sim GS, Lee BC, Cho HS, Lee JW, Kim JH, Lee DH, Kim JH, Pyo HB, Moon DC, Oh KW, et al. 2007. Structure activity relationship of antioxidative property of flavonoids and inhibitory effect on matrix metalloproteinase activity in UVA-irradiated human dermal fibroblast. Arch Pharmacol Res. 30:290–298.

Mori M, Ikeda N, Kato Y, Minamino M , Watabe K. (2002) Inhibition of elastase activity by essential oils in vitro. Journal of Cosmetic Dermatology,1(4)183-187

Lee KK, Choi JD (1999) The Effects of Areca Catechu L Extract on Anti-Aging International Journal of Cosmetic Science21(4)285-295

Beith J, Spiess B, Wermuth CG (1974). The synthesis and analytical use of a highly sensitive and convenient substrate of elastase. Biochemical Medicine 11: 350-357.

Braca A, Sortino C, Politi M et al. Anti-oxidant activity of flavonoids from Licania licaniaeflora. J Ethnopharmacol 79: 379-381, 2002.

Assaf H, Adly MA, Hussein MR. 2010. Aging and intrinsic aging: pathogenesis and manifestations. In: Farage MA, Miller KW, Maibach HI, editors. Textbook of aging skin. Heidelberg: Springer. p. 129–138

Demeule M, Brossard M, Page M, Gingras D, Beliveau R. 2000. Matrix metalloproteinase inhibition by green tea catechins. Biochim Biophys Acta. 1478:51–60.

Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S, Voorhees JJ. 2002. Mechanisms of photoaging and chronological skin aging. Arch Dermatol. 138:1462–1470.

Sim GS, Lee BC, Cho HS, Lee JW, Kim JH, Lee DH, Kim JH, Pyo HB, Moon DC, Oh KW, 2007. Structure activity relationship of antioxidative property of flavonoids and inhibitory effect on matrix metalloproteinase activity in UVA-irradiated human dermal fibroblast. Arch Pharmacol Res. 30:290–298.




DOI: https://doi.org/10.21746/aps.2017.6.12.19



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