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In-vitro antioxidant and anti-inflammatory potential of ethanol extracts (root and aerial parts) of Barleria noctiflora

Manjula M.S., Saravana Ganthi


Barleria noctiflora L.f. (Acanthaceae) is widely used as folk medicine. In the present study ethanol extracts of root and aerial parts of Barleria noctiflora were prepared using soxhlet extractor. Anti-oxidant potential was evaluated by free radical scavenging activity on DPPH and in vitro anti- inflammation activity of the selected samples stood determined by inhibition of protein denaturation experiment and inhibition of α-amylase studies. Among the root and aerial parts of Barleria noctiflora samples root sample shows significantly high level of antioxidant and anti-inflammatory activity.


antioxidant, inflammation, Acanthaceae, Barleria noctiflora

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Athar, Kosmulalage, Kalhari, and Radhika. “Chemical constituents of Barleria prionitis and their enzyme inhibitory and free radical scavenging activities”. Phytochem. Lett 2 (2009):37-40.

Benzie. “Evolution of dietary antioxidants”. Comp. Biochem. Physiol. A Mol. Integ. Physiol. 136 (2003): 113-126.

Blois. “Antioxidant determinations by the use of a stable free radical”. Nature 26 (1958): 1199-1200.

Daya, Chothani, and Mishra. “In-vitro anti-oxidant activity of Ruellia tuberosa root extracts”. Free Radicals and Antioxidants., 2.4 (2012) :38-44.

Duangporn Premjet, Siripong Premjit, Raden Arthur Ario Lenodo, and Sanro Tachibana. “Callus induction and determination of Iridoid glycosides from Barleria prionities Linn. Leaf explants”. Australian J. Basic Appl. Sci. 4.9 (2010): 4461-4467.

Grant, Alburn, and Kryzanauskas. “Stabilization of serum albumin by anti-inflammatory drugs. Biochem”. Pharmacol., 19 (1970):715 -722.

Jassim, and Naji. “Novel antiviral agents: a medicinal plant perspective”. J. Appl. Microbiol., 95(2003):412-427.

Kawal, Vasisht, and Karan. “Acute and sub-acute anti-inflammatory evaluation with chemical studies on two species of an indigenous drug ‘Barleria’”. J. Pharm Biomed Sci. 6.11 (2014): 63-68.

Kumaran, and Karunakaran. “In-vitro antioxidant activities of methanol extracts of five Phyllanthus species from India”. LWT- Food Science and Technology40 (2007): 344-52.

Madhu, Chinnaiah, and Swamy. “Traditional herbal remedies to cure asthma in Adilabad district”. IJPLS 1.4 (2010): 217-221.

Marles, and Farnsworth. “Antidiabetic plants and their active constituents”. Phytomedicine 2 (1995):137-189.

Mizushima. “Screening test for anti-rheumatic drugs”. Lancet (1966) 2:443.

Oh. “Oxidative damages are critical in pathogenesis of reflux esophagitis implication of antioxidants in its treatment”. Free Radic. Biol. Med. 30 (2001): 905- 915.

Osawa. “Novel natural antioxidants for utilization in food and biological systems. In: Uritani I, Garcia VV, Mendoza EM (Eds) Post harvest biochemistry of plant food-materials in the tropics”. Japan Scientific Societies Press, Japan. (1994), 241-251.

Oyaizu. “Studies on product of browning reaction prepared from glucose amine”. Japanese J. Nutrition, 44(1986): 307-315.

Ranjit Singh, Rajasree, and Sankar. “Screening for anti-diabetic activity of the ethanolic extract of Barleria cristata seeds”. Inter. J. Pharm. & Life Sci. 3.10 (2012): 2044-2047.

Rashmi, Laxmivenkatesh, Nargund, and Kuntal Hazra. “Thienopyrimidines as novel anti-inflammatory agents and antioxidants”. Der. Chemical inica 2.2 (2011), 165- 171.

Robert, and Turner. “Screening Methods in Pharmacol”. (2009) 152-153.

Saima Jalil, Bozhanka Mikhova, Rilka Taskova, and Maya Mitova. “In-vitro anti-inflammatory effect of Carthamus lanatus L". Z. Naturforsch 58c (2003): 830-832.

Sandhya Lakheda, Roopam Devalia, Umesh, Jain, Nilesh Gupta, Ajay Raghuwansi, and Neeraj Patidar. “Anti-inflammatory activity of Artocarpus heterophyllus bark”. Der. Pharmacia Sinica 2.2 (2011):127-130.

Sangilimuthu Alagar Yadav, Anitha Jabamalai Raj, and Sathishkumar. “In vitro antioxidant activity of Barleria noctiflora L. f.” Asian pacific journal of tropical biomedicine, (2012):S716-S722.

Shahidi, Janitha, and Wanasundara. “antioxidants. CRC Critical Rev”. Food Science and Nutrition. 32.1 (1992): 67-103.

Shankar, and Yadav. “Revision of the genus Barleria (Acanthaceae) in India”. Rheedea. 20.2 (2010): 81-130.

Shravankumar, Kishore, Siva kumar, and Sindhupriya. “In-vitro anti-inflammatory and anti-arthritic activity of leaves of Physalis angulata L”. Inter. J. Pharm. and Ind. Res.1.3 (2011):211-213.

Soares, Dins, Cunha, and Ameida. “Antioxidant activity of some extracts of Thymus zygis”. Free Radic Res. 26(1997): 469–78.

Suba, Murugesan, Kumararavelrajan, Mandal, and Saha. “Antiinflammatory, analgesic and antiperoxidative efficacy of Barleria lupulina Lindl. Extract”. Phytother. Res. 19(2005): 695-699.

Suba, Murugesan, Arunachalam, Mandal, and Saha. “Anti-diabetic potential of Barleria lupulina extract in rats”. Phytomed 11(2004):202-205.

Tripathi. “Essential of medical pharmacol”. Pharmaceutical Technology 5 (2004): 257-259.

Wetson, Zorb, and John. “High phenotypic plasticity of Suaeda maritima observed under hypoxic conditions in relation to its physiological basis”. Annals of Botany (2012) 1-10.

Yogamoorthi, and Sathya Priya. “Antiinflammatory and analgesic property of methanolic extract of Spinifex littoreus (Burm.f.) Merr.” J. Environmental Biology 27.2 (2006): 271-273.

Yokozawa, Chen, Dong, Tanaka, Nonaka, and Nishioka. “Study on the inhibitory effect of tannins and flavonoids against the 1, 1-Diphenyl-2- picrylhydrazyl radical”. Biochem. Pharm. 56 (1998):213-222.

Zeng, Deng, and Zhang. “Cloning of Salt Tolerance-Related cDNAs from the Mangrove Plant Sesuvium portulacastrum L.” J. Integrative Plant Biology 48.8 (2006): 952-957.

Zeynep, Kosar, and Kupeli. “Antioxidant, anti-inflammatory, antinociceptive activities and composition of Lythrum salicaria L. extracts”. J. Ethnopharmacol 110 (2007): 539-547.



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